Protein toxins: intracellular trafficking for targeted therapy
نویسندگان
چکیده
منابع مشابه
Differences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants
Objective(s): Mutant forms FMS-like tyrosine kinase-3 (FLT3), are reported in 25% of childhood acute lymphoid leukemia (ALL) and 30% of acute myeloid leukemia (AML) patients. In this study, drug response, growth promoting, and protein trafficking of FLT3 wild-type was compared with two active mutants (Internal Tandem Duplication (ITD)) and D835Y. Materials and Methods:FLT3 was expressed on fact...
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متن کاملdifferences in growth promotion, drug response and intracellular protein trafficking of flt3 mutants
objective(s): mutant forms fms-like tyrosine kinase-3 (flt3), are reported in 25% of childhood acute lymphoid leukemia (all) and 30% of acute myeloid leukemia (aml) patients. in this study, drug response, growth promoting, and protein trafficking of flt3 wild-type was compared with two active mutants (internal tandem duplication (itd)) and d835y. materials and methods:flt3 was expressed on fact...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2005
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3302557